Description

N,N′-Bis-tert-Butoxycarbonylthiourea is a high-purity, protected thiourea derivative widely used as a critical building block in organic synthesis. Its primary value lies in providing a versatile and stable source of the thiourea moiety under controlled reaction conditions, enabling the synthesis of complex heterocycles and pharmaceuticals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for peptide mimetics, kinase inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of thiourea-based drug candidates, including kinase inhibitors and antiviral agents.
• Peptidomimetic Synthesis: Serves as a protected scaffold for introducing thiourea bridges into peptide analogs to enhance stability and biological activity.
• Heterocyclic Chemistry: Fundamental building block for constructing sulfur-containing heterocycles like thiazoles and imidazolidine-2-thiones.
• Agrochemical Research: Used in developing novel fungicides and herbicides that utilize the thiourea pharmacophore.
• Chemical Biology Probes: Employed in creating activity-based probes and molecular tags for studying enzyme mechanisms.
• Polymer Modification: Acts as a functional monomer or cross-linking agent in specialty polymer synthesis.

Basic Information

Product Name	N,N′-Bis-tert-Butoxycarbonylthiourea
CAS No.	145013-05-4
Molecular Formula	C11H20N2O4S
Molecular Weight	276.35 g/mol
Synonyms	1,3-Bis(tert-butoxycarbonyl)thiourea; Di-Boc-thiourea; N,N'-Di-Boc-thiourea; tert-Butyl N-[(tert-butoxycarbonyl)carbamothioyl]carbamate; Thiourea, 1,3-bis[(1,1-dimethylethoxy)carbonyl]-; BOC-Thiourea; Bis-Boc-thiourea; 1,3-Di-tert-butyloxycarbonyl-2-thiourea
EINECS	Contact for details

Quality Control

Our N,N′-Bis-tert-Butoxycarbonylthiourea is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable supply for critical development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.