Description

3,5-Difluoro-Benzamidine Hydrochloride is a high-purity, halogenated benzamidine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role as a versatile amidine precursor, enabling the introduction of the amidine functional group into complex molecular architectures under controlled conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging the difluoro-substituted aromatic core.
• Chemical Biology & Proteomics: Serves as a precursor for affinity probes and activity-based protein profiling (ABPP) reagents targeting serine proteases.
• Material Science: Employed in the creation of specialty polymers and ligands for metal-organic frameworks (MOFs) due to its chelating potential.
• Academic & Contract Research: Utilized in methodological development and exploratory organic chemistry research.

Basic Information

Product Name	3,5-Difluoro-Benzamidine Hydrochloride
CAS No.	144797-68-2
Molecular Formula	C7H7ClF2N2
Molecular Weight	192.59 g/mol
Synonyms	3,5-Difluorobenzamidine hydrochloride; 3,5-Difluorobenzene carboximidamide hydrochloride; Benzenecarboximidamide, 3,5-difluoro-, hydrochloride (1:1); 3,5-Difluorobenzamidine HCl; 3,5-Difluorobenzamidine monohydrochloride; 3,5-Difluoro-benzenecarboximidamide hydrochloride
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-Benzamidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.