Description

Methanesulfonic Acid, 1,1,1-Trifluoro-, 5,6,7,8-Tetrahydro-5-Oxo-2-Naphthalenyl Ester is a specialized fluorinated sulfonate ester building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular architecture, which combines a reactive ester linkage with a trifluoromethylsulfonyl group and a tetralone-derived moiety, making it a versatile intermediate for constructing complex molecules. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring the introduction of fluorinated sulfonate ester groups for enhanced metabolic stability or bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the specific fluorinated tetralone structure can contribute to unique biological activity.
• Advanced Material Synthesis: Serves as a monomer or precursor in the creation of specialty polymers and functional materials with tailored properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, esterification processes, and as a protecting group or activating agent in multi-step synthetic pathways.
• Chemical Biology Probe Development: Useful for labeling or modifying biomolecules in research aimed at understanding biological pathways and target engagement.

Basic Information

Product Name	Methanesulfonic Acid, 1,1,1-Trifluoro-, 5,6,7,8-Tetrahydro-5-Oxo-2-Naphthalenyl Ester
CAS No.	144464-64-2
Molecular Formula	C₁₂H₉F₃O₄S
Molecular Weight	306.26 g/mol
Synonyms	5,6,7,8-Tetrahydro-5-oxo-2-naphthalenyl trifluoromethanesulfonate; 2-(Trifluoromethanesulfonyloxy)-5,6,7,8-tetrahydro-5-oxonaphthalene; 5-Oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate; 1,1,1-Trifluoro-N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)methanesulfonamide ester; Trifluoromethanesulfonic acid 5,6,7,8-tetrahydro-5-oxo-2-naphthalenyl ester; 2-Naphthalenol, 5,6,7,8-tetrahydro-5-oxo-, 1,1,1-trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), impurity profile, and physical characteristics are available upon request. We adhere to a cGMP-compliant quality management system suitable for supporting pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.