Description

2-(4-Chloro-Phenoxy)-1-Piperazin-1-Yl-Ethanone is a high-purity chemical building block featuring a piperazine core linked to a chlorophenoxy moiety. This compound is valued for its role as a versatile intermediate in the synthesis of more complex active pharmaceutical ingredients (APIs) and agrochemicals. It is essential for research and development chemists and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable, high-quality intermediates for scale-up and manufacturing.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the development and manufacturing of advanced herbicides and pesticides, leveraging the chlorophenoxy group's bioactivity.
• Chemical Research & Development: Serves as a crucial building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the synthesis pathway of final API compounds requiring a functionalized piperazine derivative.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for metal-catalyzed reactions or as a precursor for catalyst systems.

Basic Information

Product Name	2-(4-Chloro-Phenoxy)-1-Piperazin-1-Yl-Ethanone
CAS No.	143999-83-1
Molecular Formula	C12H15ClN2O2
Molecular Weight	254.71 g/mol
Synonyms	1-[2-(4-Chlorophenoxy)acetyl]piperazine; 2-(4-Chlorophenoxy)-1-(piperazin-1-yl)ethanone; 4-Chlorophenoxyacetylpiperazine; N-(4-Chlorophenoxyacetyl)piperazine; 1-(4-Chlorophenoxyacetyl)piperazine; 2-(p-Chlorophenoxy)-1-piperazin-1-ylethanone; Ethanone, 2-(4-chlorophenoxy)-1-(1-piperazinyl)-; 143999-83-1
EINECS	Contact for details

Quality Control

Our 2-(4-Chloro-Phenoxy)-1-Piperazin-1-Yl-Ethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for use in critical synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.