Description

Diboc-Iodo-L-Dopa CAS NO 143993-89-9 is a protected, iodinated derivative of the essential amino acid L-DOPA, serving as a crucial advanced intermediate in modern organic synthesis. This compound is specifically engineered to facilitate the controlled introduction of the L-DOPA pharmacophore into complex molecular architectures while protecting sensitive functional groups. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly for neurological disorders and targeted radiopharmaceuticals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel dopamine receptor agonists, antagonists, and other central nervous system (CNS) active compounds.
• Radiopharmaceutical Precursor: Serves as a precursor for iodine-123 or iodine-131 labeled compounds used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) imaging agents.
• Peptide & Protein Modification: Used to incorporate iodinated tyrosine analogs into peptides and proteins for structural studies, labeling, or creating novel bioconjugates.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by allowing precise modification of the catechol moiety in drug candidates.
• Chemical Biology Probes: Facilitates the creation of molecular probes for studying dopamine transport, metabolism, and receptor interactions.
• Asymmetric Synthesis: Provides a chiral, protected template for the synthesis of complex natural products and bioactive molecules.

Basic Information

Product Name	Diboc-Iodo-L-Dopa
CAS No.	143993-89-9
Molecular Formula	C19H26INO6
Molecular Weight	491.32 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3,4-bis[(tert-butoxycarbonyl)oxy]-5-iodophenyl)propanoic acid; N-Boc-3-Iodo-L-DOPA bis(Boc) ester; 3-Iodo-L-DOPA bis(tert-butyl) ester N-Boc derivative; Boc-Iodo-DOPA(Boc)2; N-(tert-Butoxycarbonyl)-3-iodo-L-tyrosine bis(tert-butyl) ester; 3-Iodo-N-Boc-L-DOPA(Boc)2; L-DOPA derivative, iodinated, Boc-protected
EINECS	Contact for details

Quality Control

Our Diboc-Iodo-L-Dopa is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.