Description

D-Glucopyranose, 2,3,4,6-Tetraacetate 1-(2,2,2-Trichloroethanimidate) is a key glycosylation donor and advanced synthetic intermediate in carbohydrate chemistry. This compound is valued for its role in the stereoselective construction of glycosidic bonds, enabling the synthesis of complex oligosaccharides and glycoconjugates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic agents, and bioactive molecules. The CAS number for this compound is 142831-80-9.

Application

• Glycosylation Reactions: Serves as a crucial donor molecule for the stereoselective synthesis of O-glycosides and oligosaccharides.
• Pharmaceutical Intermediate: Used in the research and development of carbohydrate-based drugs, including antibiotics, antivirals, and anticancer agents.
• Glycoconjugate Synthesis: Essential for creating glycoproteins, glycolipids, and other biologically active glycoconjugates for biochemical studies.
• Chemical Biology Probes: Employed in the synthesis of labeled sugars and probes for studying carbohydrate-protein interactions and metabolic pathways.
• Process Development: Used in scaling up synthetic routes for complex carbohydrate targets in both academic and industrial settings.

Basic Information

Product Name	D-Glucopyranose, 2,3,4,6-Tetraacetate 1-(2,2,2-Trichloroethanimidate)
CAS No.	142831-80-9
Molecular Formula	C16H20Cl3NO9
Molecular Weight	484.69 g/mol
Synonyms	2,3,4,6-Tetra-O-acetyl-α-D-glucopyranosyl trichloroacetimidate; α-D-Glucopyranose, 2,3,4,6-tetraacetate 1-(2,2,2-trichloroethanimidate); Trichloroacetimidate Glycosyl Donor; Glucosyl Trichloroacetimidate (peracetylated); Glycosylating Agent; TCAI Donor (Glucose); 1-O-Trichloroacetimidoyl-2,3,4,6-tetra-O-acetyl-α-D-glucopyranose
EINECS	Contact for details

Quality Control

Our D-Glucopyranose, 2,3,4,6-Tetraacetate 1-(2,2,2-Trichloroethanimidate) is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can compromise reactivity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation [α]²⁰D	+80° to +85° (c=1 in CHCl₃)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.