Description

2,3-Dehydrosilybin B is a high-purity flavonolignan derivative, a key intermediate and reference standard in advanced phytochemical research and development. This compound is valued for its role in studying the structure-activity relationships and metabolic pathways of silymarin complex constituents. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, nutraceutical, and analytical chemistry sectors for method development, quality control, and bioactive compound synthesis.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and purity testing of silymarin and related flavonolignan products in compliance with pharmacopeial methods (e.g., USP, EP).
• Biochemical Research: Serves as a critical intermediate or probe in studies investigating hepatoprotective mechanisms, antioxidant activity, and metabolic transformation of flavonolignans.
• Nutraceutical Ingredient Development: Employed in the research and formulation of standardized, high-efficacy milk thistle extracts and specialized dietary supplements.
• Analytical Chemistry: Essential for HPLC and LC-MS method development, validation, and as a calibration standard for quantitative analysis in complex matrices.
• Organic Synthesis: Acts as a sophisticated building block or precursor for the semi-synthesis of novel derivatives with potential enhanced bioactivity.

Basic Information

Product Name	2,3-Dehydrosilybin B
CAS No.	142796-24-5
Molecular Formula	C25H20O10
Molecular Weight	480.42 g/mol
Synonyms	2,3-Dehydrosilybin B; 2,3-Dehydrosilibinin B; 3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-4H-1-benzopyran-4-one; Dehydrosilybin B; 2,3-Didehydrosilybin B; 2,3-Anhydrosilybin B; (2R,3R)-2,3-Dehydrosilybin B; A flavonolignan from Silybum marianum.
EINECS	Contact for details

Quality Control

Our 2,3-Dehydrosilybin B is produced and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.