Description

(R)-4-Acetylthio-2-Pyrrolidinone CAS NO 142705-97-3 is a high-purity, chiral pyrrolidinone derivative characterized by a reactive acetylthio functional group. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate in the synthesis of complex, biologically active molecules. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in neurological and metabolic disorder research.
• Asymmetric Synthesis: Utilized as a versatile chiral precursor in stereoselective synthesis to introduce the pyrrolidinone scaffold with defined stereochemistry.
• Protease Inhibitor Research: Serves as a core structural element in the design and synthesis of protease inhibitor candidates.
• Agrochemical Development: Employed in the research phase for creating new chiral active ingredients with specific biological activity.
• Ligand and Catalyst Preparation: Used in the preparation of chiral ligands and organocatalysts for catalytic asymmetric transformations.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(R)-4-Acetylthio-2-Pyrrolidinone
CAS No.	142705-97-3
Molecular Formula	C6H9NO2S
Molecular Weight	159.21 g/mol
Synonyms	(R)-4-(Acetylthio)-2-pyrrolidinone; (R)-4-(Acetylsulfanyl)pyrrolidin-2-one; (4R)-4-Acetylthio-2-pyrrolidinone; (R)-4-Acetylthio-2-pyrrolidone; (R)-4-Acetylsulfanyl-2-pyrrolidinone; 4-Acetylthio-2-pyrrolidinone, (R)-; 142705-97-3; (R)-NSC 339776
EINECS	Contact for details

Quality Control

Our (R)-4-Acetylthio-2-Pyrrolidinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.