Description

Methyl [E]-2-[3-(S)-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-3-Hydroxypropyl]Benzoate is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for research and development in the synthesis of novel therapeutic agents, particularly those targeting inflammatory pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring a reliable, high-quality building block for complex organic synthesis.

Application

• Key Intermediate in Montelukast Synthesis: Serves as a crucial precursor in the production of Montelukast sodium, a leukotriene receptor antagonist used in asthma and allergy medications.
• Pharmaceutical R&D: Employed in the research and development of new drug candidates targeting cysteinyl leukotriene receptors (CysLT1).
• Fine Chemical Synthesis: Used as a sophisticated chiral building block for constructing complex molecules in medicinal chemistry.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry Development: Utilized for scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Methyl [E]-2-[3-(S)-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-3-Hydroxypropyl]Benzoate
CAS No.	142569-69-5
Molecular Formula	C28H24ClNO3
Molecular Weight	457.95 g/mol
Synonyms	Montelukast Intermediate; (S)-Methyl 2-(1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)benzoate; (S)-Methyl 2-(3-(3-(2-(7-Chloro-2-quinolyl)vinyl)phenyl)-3-hydroxypropyl)benzoate; Methyl (S)-2-[3-[3-[(E)-2-(7-Chloro-2-quinolyl)vinyl]phenyl]-3-hydroxypropyl]benzoate; L-706,631 (acid form intermediate); MK-0476 Intermediate; 142569-69-5; (S)-enantiomer of Montelukast key intermediate.
EINECS	Contact for details

Quality Control

Our Methyl [E]-2-[3-(S)-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-3-Hydroxypropyl]Benzoate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.