Description

n-[(3S,4S,4As,5R)-3-(Dichloromethyl)-1,5-Dihydroxy-3-Methyl-8-Oxo-4A,5,6,7-Tetrahydro-4H-Isochromen-4-Yl]-2-Amino-Propanamide is a high-purity, complex organic compound with significant potential in advanced pharmaceutical research and development. This molecule is valued for its intricate stereochemistry and functional groups, which make it a critical building block or intermediate in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in areas requiring sophisticated chiral synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of potential new drug candidates.
• Research Chemical: Used in academic and industrial research to study structure-activity relationships (SAR) and develop new synthetic methodologies.
• Precursor for Active Pharmaceutical Ingredients (APIs): A critical intermediate in the production pathway for specialized, high-value pharmaceuticals.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes from laboratory to pilot plant and commercial production.
• Biochemical Research: Potential use in probing biological pathways or as a template for designing enzyme inhibitors due to its complex structure.

Basic Information

Product Name	n-[(3S,4S,4As,5R)-3-(Dichloromethyl)-1,5-Dihydroxy-3-Methyl-8-Oxo-4A,5,6,7-Tetrahydro-4H-Isochromen-4-Yl]-2-Amino-Propanamide
CAS No.	142429-34-3
Molecular Formula	C15H20Cl2N2O5
Molecular Weight	379.24 g/mol
Synonyms	2-Amino-N-[(3S,4S,4aS,5R)-3-(dichloromethyl)-1,5-dihydroxy-3-methyl-8-oxo-4a,5,6,7-tetrahydro-4H-isochromen-4-yl]propanamide; (3S,4S,4aS,5R)-4-[(2-Aminopropanoyl)amino]-3-(dichloromethyl)-1,5-dihydroxy-3-methyl-4a,5,6,7-tetrahydro-4H-isochromen-8-one; CAS 142429-34-3; Complex Isochromanone Derivative; Chiral Dichloromethyl Isochromenone Amide.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, chiral purity, and impurity profiles. We support development projects with GMP-grade manufacturing capabilities upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under dry conditions or an inert atmosphere to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.