Description

3-Hydroxy-3,3A,4,6A-Tetrahydro-2H-Cyclopenta[B]Furan-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused bicyclic lactone structure. This compound is of significant commercial interest for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical sectors engaged in developing novel therapeutic agents, particularly those targeting central nervous system and metabolic disorders.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of prostaglandin analogs and other complex bioactive molecules.
• Organic Synthesis Building Block: Used in asymmetric synthesis and cyclization reactions to construct intricate molecular architectures.
• Medicinal Chemistry Research: Serves as a core scaffold for drug discovery programs, enabling the exploration of new chemical entities.
• Process Development: Employed in the scale-up and optimization of synthetic routes for target APIs in pilot plants and commercial manufacturing.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	3-Hydroxy-3,3A,4,6A-Tetrahydro-2H-Cyclopenta[B]Furan-2-One
CAS No.	141554-44-1
Molecular Formula	C7H8O3
Molecular Weight	140.14 g/mol
Synonyms	3-Hydroxy-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one; (3aS,6aR)-3-Hydroxy-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one; 3-Hydroxy-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one; 3-Hydroxy-3,3a,4,6a-tetrahydro-2H-cyclopentafuran-2-one; 2H-Cyclopenta[b]furan-2-one, 3,3a,4,6a-tetrahydro-3-hydroxy-; 3-Hydroxy-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one (enantiomer); Cyclopentafuranone derivative
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-3,3A,4,6A-Tetrahydro-2H-Cyclopenta[B]Furan-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.