Description

Trt-Peg2-Otos CAS NO 141282-25-9 is a specialized bifunctional PEG-based reagent featuring a trityl (Trt) protecting group and a reactive tosylate (Otos) moiety. This compound is a critical intermediate in the synthesis of complex molecules, enabling precise conjugation and controlled release strategies. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for developing targeted drug delivery systems, antibody-drug conjugates (ADCs), and advanced polymer therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation Reagent: Used for the controlled attachment of drugs, dyes, or other functional molecules to proteins, peptides, or antibodies.
• ADC (Antibody-Drug Conjugate) Development: Facilitates the creation of stable, cleavable linkers between cytotoxic payloads and monoclonal antibodies.
• Polymer Chemistry: Serves as a functional initiator or monomer in the synthesis of tailored, biocompatible PEG-based polymers and hydrogels.
• Prodrug Synthesis: Enables the design of prodrugs with specific, stimuli-responsive release mechanisms.
• Material Science: Used to modify surface properties and introduce functional groups onto nanomaterials and biomaterials.

Basic Information

Product Name	Trt-Peg2-Otos
CAS No.	141282-25-9
Molecular Formula	C31H38O5S
Molecular Weight	522.70 g/mol
Synonyms	Trityl-PEG2-tosylate; 2-[2-[4-Methylbenzenesulfonyloxy]ethoxy]ethoxy-methyl-triphenylmethane; 4-Methylbenzenesulfonic acid 2-[2-(triphenylmethoxy)ethoxy]ethyl ester; Triphenylmethyl-PEG2-OTs; Trt-O-(CH2CH2O)2-OTs; Trt-PEG2-OTs; Monomethoxytrityl-PEG2-tosylate (common alias); PEG2-tosylate trityl ether
EINECS	Contact for details

Quality Control

Our Trt-Peg2-Otos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment upon receipt.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.