Description

[3Ar-(3Aα,4α,6Aα)]-4-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]Hexahydro-2H-Cyclopenta[B]Furan-2-One is a high-purity, advanced pharmaceutical intermediate featuring a protected hydroxyl group via a tert-butyldiphenylsilyl (TBDPS) moiety. This compound is critical for its role as a key chiral building block in the synthesis of complex, biologically active molecules, particularly in prostaglandin and prostacyclin analog research. It is essential for R&D and production chemists in the pharmaceutical and fine chemical industries who require high-stereochemical purity and reliable protecting group strategies for multi-step synthetic routes.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the multi-step synthesis of prostaglandin analogs and related therapeutic agents.
• Organic Synthesis Building Block: Used in complex organic transformations where a protected alcohol functionality is required for selective reactions.
• Medicinal Chemistry Research: Serves as a key starting material or intermediate in drug discovery programs targeting inflammation, cardiovascular diseases, and ocular conditions.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.
• Academic & Industrial R&D: Utilized in laboratories for developing new synthetic methodologies and exploring structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	[3Ar-(3Aα,4α,6Aα)]-4-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]Hexahydro-2H-Cyclopenta[B]Furan-2-One
CAS No.	140690-09-1
Molecular Formula	C25H32O3Si
Molecular Weight	408.61 g/mol
Synonyms	(3aR,4R,6aR)-4-(((tert-Butyldiphenylsilyl)oxy)methyl)hexahydro-2H-cyclopenta[b]furan-2-one; TBDPS-protected Lactone Intermediate; tert-Butyldiphenylsilyl Ether of Hydroxymethyl Lactone; Prostaglandin Intermediate; 4-((tert-Butyldiphenylsilyloxy)methyl)hexahydro-2H-cyclopenta[b]furan-2-one (enantiomer); (3aR-(3aalpha,4alpha,6aalpha))-4-(((1,1-Dimethylethyl)diphenylsilyl)oxy)methyl)hexahydro-2H-cyclopenta[b]furan-2-one
EINECS	Contact for details

Quality Control

Our [3Ar-(3Aα,4α,6Aα)]-4-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]Hexahydro-2H-Cyclopenta[B]Furan-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.