Description

2,3,4,6-Tetra-o-Benzyl-1-C-Dichloromethyl-D-Glucopyranose is a key protected carbohydrate intermediate, specifically a benzylated glycosyl donor with a reactive dichloromethyl group at the anomeric center. This compound is critical for the stereoselective synthesis of complex oligosaccharides and C-glycosides, offering precise control over glycosidic bond formation. It is an essential building block for pharmaceutical R&D, particularly in the development of antiviral agents, enzyme inhibitors, and other bioactive glycoconjugates.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel antiviral and antibacterial drugs, especially nucleoside analogs.
• C-Glycoside Synthesis: Serves as a key electrophile for the construction of stable C-glycosidic linkages, which are resistant to enzymatic hydrolysis.
• Oligosaccharide & Glycoconjugate Assembly: Used in block synthesis strategies to build complex carbohydrate chains for biological studies and drug discovery.
• Glycochemistry Research: Employed in academic and industrial laboratories for developing new glycosylation methodologies and protecting group strategies.
• Precursor to Other Protected Sugars: Can be further functionalized to generate a library of specialized monosaccharide donors for combinatorial chemistry.

Basic Information

Product Name	2,3,4,6-Tetra-o-Benzyl-1-C-Dichloromethyl-D-Glucopyranose
CAS No.	140658-50-0
Molecular Formula	C35H36Cl2O5
Molecular Weight	607.56 g/mol
Synonyms	1-C-(Dichloromethyl)-2,3,4,6-tetra-O-benzyl-D-glucopyranose; 2,3,4,6-Tetra-O-benzyl-1-C-dichloromethyl-D-glucopyranose; 1-C-Dichloromethyl-2,3,4,6-tetra-O-benzyl-D-glucopyranose; Tetra-O-benzyl-1-C-dichloromethyl-D-glucopyranose; D-Glucopyranose, 1-C-(dichloromethyl)-2,3,4,6-tetra-O-benzyl-; 1-C-Dichloromethyl-2,3,4,6-tetra-O-benzyl-alpha/β-D-glucopyranose
EINECS	Contact for details

Quality Control

Our 2,3,4,6-Tetra-o-Benzyl-1-C-Dichloromethyl-D-Glucopyranose is manufactured under strict quality systems to ensure batch-to-batch consistency for critical synthetic applications. Each lot is characterized by advanced analytical techniques including NMR (¹H & ¹³C) and HPLC to confirm identity, isomeric purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
α/β Isomer Ratio (by NMR)	Reported on COA
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.