Description

Trifluoro-Methanesulfonic Acid Isoquinolin-5-Yl Ester is a specialized triflate ester derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. Its core value lies in its exceptional reactivity as an alkylating or arylating agent, facilitating the efficient construction of complex heterocyclic and pharmaceutical scaffolds. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for building novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing isoquinoline or related nitrogen heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic motifs.
• Ligand & Catalyst Precursor: Employed in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Buchwald-Hartwig).
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs or conductive polymers.
• Chemical Biology Probes: Utilized to create tagged or modified biomolecules for studying biological pathways and protein interactions.

Basic Information

Product Name	Trifluoro-Methanesulfonic Acid Isoquinolin-5-Yl Ester
CAS No.	140202-00-2
Molecular Formula	C₁₁H₆F₃NO₃S
Molecular Weight	289.23 g/mol
Synonyms	5-Isoquinolinyl Trifluoromethanesulfonate; 5-Isoquinolinyl Triflate; Isoquinolin-5-yl Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid 5-Isoquinolinyl Ester; 5-(Trifluoromethanesulfonyloxy)isoquinoline; 5-OTf Isoquinoline; 5-Triflyloxyisoquinoline
EINECS	Contact for details

Quality Control

Our Trifluoro-Methanesulfonic Acid Isoquinolin-5-Yl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles against established specifications. We support cGMP and ISO 9001 standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.