Description

(R)-1-Tosyloxy-3-Buten-2-Ol CAS NO 138249-07-7 is a high-purity chiral building block and key intermediate in organic synthesis. Its value lies in its role as a versatile electrophile for introducing the (R)-configured butenol moiety, enabling the stereoselective construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure drugs, including potential antiviral and anticancer agents.
• Asymmetric Synthesis: Used in palladium-catalyzed cross-coupling reactions and nucleophilic substitution reactions to create carbon-carbon and carbon-heteroatom bonds with high stereocontrol.
• Natural Product Synthesis: Serves as a building block for the total synthesis of complex natural products containing chiral alcohol or epoxide functionalities.
• Ligand and Catalyst Preparation: A precursor for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Material Science Research: Employed in the development of chiral polymers and advanced organic materials with specific optical properties.

Basic Information

Product Name	(R)-1-Tosyloxy-3-Buten-2-Ol
CAS No.	138249-07-7
Molecular Formula	C11H14O4S
Molecular Weight	242.29 g/mol
Synonyms	(R)-1-[(4-Methylphenyl)sulfonyl]oxy-3-buten-2-ol; (R)-2-Hydroxy-3-butenyl 4-toluenesulfonate; (R)-3-Butene-1,2-diol 1-tosylate; (R)-1-Tosyloxy-3-buten-2-ol; (R)-2-Hydroxy-3-buten-1-yl tosylate; (R)-1-O-Tosyl-3-buten-2-ol; (R)-Tosyloxybutenol; (R)-TBOT
EINECS	Contact for details

Quality Control

Our (R)-1-Tosyloxy-3-Buten-2-Ol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.