Description

Poly(2-Propylacrylic Acid) is a synthetic, pH-responsive polymer known for its unique membrane-disruptive properties under mildly acidic conditions. This functionality makes it a critical material for advanced drug delivery systems, particularly for the targeted release of therapeutic agents. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors.

Application

• pH-Responsive Drug Delivery: As a key component in the design of "smart" carriers for cancer therapeutics, enabling triggered release in the acidic tumor microenvironment.
• Endosomal Escape Agent: To enhance the cytosolic delivery of biomacromolecules (e.g., DNA, siRNA, proteins) by disrupting endosomal membranes following cellular uptake.
• Polymeric Micelle & Nanoparticle Formation: Serves as a building block for self-assembling nanostructures that encapsulate hydrophobic drugs.
• Gene Transfection: Used in non-viral vector formulations to improve the efficiency of gene delivery into cells.
• Biomaterial Coatings: For creating surfaces with stimuli-responsive properties for controlled cell adhesion or release.
• Research & Development: A valuable tool in academic and industrial R&D for studying membrane interactions and developing novel therapeutic platforms.

Basic Information

Product Name	Poly(2-Propylacrylic Acid)
CAS No.	138134-74-4
Molecular Formula	(C6H10O2)n
Molecular Weight	Varies by polymer grade (Contact for details)
Synonyms	Poly(2-propylacrylic acid); P(2-PAA); Poly(2-propylpropenoic acid); 2-Propylacrylic Acid Homopolymer; PPAA; pH-Responsive Polymer; Membrane-Destabilizing Polymer; Endosomolytic Polymer
EINECS	Contact for details

Quality Control

Our Poly(2-Propylacrylic Acid) is produced under controlled conditions to ensure batch-to-batch consistency critical for research and formulation work. Each lot undergoes rigorous analysis, including determination of molecular weight distribution, degree of polymerization, and functional group integrity. A comprehensive Certificate of Analysis (COA) detailing purity, pH-response profile, and other key parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (Acid Content)	≥ 95% (by Titration)
Weight-Average Molecular Weight (Mw)	Customizable (e.g., 10 kDa - 200 kDa)
Polydispersity Index (PDI)	< 1.5 (by GPC)
pH-Responsive Transition	~pH 6.5 (Typical, can be tailored)
Residual Solvent	Meets ICH guidelines
Water Content	< 1.0% (by KF Titration)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.