Description

2-Chloro-2-Fluorocyclopropanecarboxylic Acid is a high-value, multifunctional cyclopropane derivative that serves as a critical building block in advanced organic synthesis. Its unique halogenated cyclopropane structure makes it an essential precursor for developing novel active pharmaceutical ingredients (APIs) and agrochemicals with enhanced properties. This compound is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for creating complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the cyclopropane ring.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials with tailored thermal or chemical resistance.
• Fluorine Chemistry Building Block: Essential for introducing both fluorine and chlorine atoms into complex molecules, a common strategy in modern drug design to modulate bioavailability and metabolic stability.
• Academic and Contract Research: Used in university and CRO laboratories for methodological development and exploring new chemical spaces.

Basic Information

Product Name	2-Chloro-2-Fluorocyclopropanecarboxylic Acid
CAS No.	137081-42-6
Molecular Formula	C4H4ClFO2
Molecular Weight	138.52 g/mol
Synonyms	2-Chloro-2-fluorocyclopropane-1-carboxylic acid; 2-Fluoro-2-chlorocyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 2-chloro-2-fluoro-; 1-Carboxy-2-chloro-2-fluorocyclopropane; 2-Chloro-2-fluoro-1-cyclopropanecarboxylic acid; 2-Fluoro-2-chloro-1-cyclopropanecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-2-Fluorocyclopropanecarboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, handle with appropriate engineering controls.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.