Description

(R)-1-((tert-Butyldimethylsilyl)Oxy)Propan-2-Ol (Wxg01849) is a high-purity, chiral organosilicon-protected alcohol, a crucial chiral building block in advanced organic synthesis. Its value lies in providing a protected hydroxyl group with defined stereochemistry, enabling the precise construction of complex molecules while preventing unwanted side reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for developing active pharmaceutical ingredients (APIs), catalysts, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in antiviral, cardiovascular, and central nervous system (CNS) drug candidates.
• Asymmetric Synthesis: Used as a chiral auxiliary or starting material in stereoselective reactions, including nucleophilic substitutions, Grignard additions, and cross-coupling reactions.
• Agrochemical Research: Serves as a building block for developing chiral pesticides, herbicides, and plant growth regulators with enhanced efficacy and environmental profile.
• Ligand and Catalyst Preparation: Employed in the synthesis of chiral ligands for transition metal catalysis, enabling highly enantioselective transformations.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, fragrances, and advanced materials where optical purity is critical.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and for exploring new synthetic pathways in academic and industrial research settings.

Basic Information

Product Name	(R)-1-((tert-Butyldimethylsilyl)Oxy)Propan-2-Ol (Wxg01849)
CAS No.	136918-07-5
Molecular Formula	C9H22O2Si
Molecular Weight	190.36 g/mol
Synonyms	(R)-1-[(tert-Butyldimethylsilyl)oxy]-2-propanol; (R)-1-(tert-Butyldimethylsiloxy)propan-2-ol; (R)-2-Propanol, 1-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; (R)-1-(TBDMSO)propan-2-ol; (R)-1-(tert-Butyldimethylsilyloxy)-2-propanol; (R)-TBDMS-protected glycerol derivative; (R)-1-TBDMS-oxy-2-propanol; (R)-1-Hydroxy-2-(tert-butyldimethylsilyloxy)propane
EINECS	Contact for details

Quality Control

Our (R)-1-((tert-Butyldimethylsilyl)Oxy)Propan-2-Ol is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC and GC, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.