Description

2H-Pyran-2-Ol, 6-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-3-Methoxy-5-(Phenylmethoxy)-2-(2-Propenyl)-, 2S-(2.Alpha.,3.Alpha.,5.Alpha.,6.Beta.)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in process chemistry, medicinal chemistry, and the production of specialized fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug molecules, particularly those with chiral centers.
• Medicinal Chemistry Research: Used in research and development for creating new chemical entities (NCEs) and exploring structure-activity relationships (SAR).
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Fine Chemical Synthesis: Employed in the production of high-value, specialty chemicals for the life sciences industry.
• Contract Manufacturing (CMO/CDMO): Supplied to contract manufacturing organizations for the production of APIs under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for synthetic organic chemistry studies and methodology development.

Basic Information

Product Name	2H-Pyran-2-Ol, 6-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-3-Methoxy-5-(Phenylmethoxy)-2-(2-Propenyl)-, 2S-(2.Alpha.,3.Alpha.,5.Alpha.,6.Beta.)-
CAS No.	136770-52-0
Molecular Formula	C23H38O4Si
Molecular Weight	406.63 g/mol
Synonyms	(2S,3S,5S,6R)-6-[(tert-Butyldimethylsilyloxy)methyl]-5-methoxy-2-(prop-2-en-1-yl)-3-(benzyloxy)tetrahydro-2H-pyran-2-ol; tert-Butyldimethyl((2S,3S,5S,6R)-5-methoxy-2-(prop-2-en-1-yl)-3-(benzyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)silane; 136770-52-0; Advanced Pyran Intermediate; TBDMS-protected Pyranol Derivative; Chiral Dihydropyran Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized using advanced analytical techniques including NMR, HPLC, and GC to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects with quality standards suitable for cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from incompatible materials such as fluorides and strong alkalis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.