Description

2H-Pyran-2-Ol, 6-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-3-Methoxy-5-(Phenylmethoxy)-2-(2-Propenyl)-, 2R-(2.Alpha.,3.Beta.,5.Beta.,6.Alpha.)- is a high-value, stereochemically defined synthetic intermediate with a complex molecular architecture. Its precise stereochemistry and functional groups make it a critical building block for advanced organic synthesis, particularly in the development of complex natural products and active pharmaceutical ingredients (APIs). This compound is essential for research and production teams in the pharmaceutical, agrochemical, and fine chemical sectors seeking to introduce specific chiral centers and protected functionalities into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates, especially those with polycyclic or glycosidic structures.
• Natural Product Synthesis: Used as a foundational fragment in the total synthesis of biologically active natural products, leveraging its tetrahydro-2H-pyran core and allyl side chain.
• Agrochemical Research: Acts as a precursor for developing novel active ingredients with specific stereochemical requirements for enhanced efficacy and selectivity.
• Methodology Development: Employed in academic and industrial R&D for developing new asymmetric synthesis and protective group strategies.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals where control over multiple stereocenters is paramount.

Basic Information

Product Name	2H-Pyran-2-Ol, 6-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-3-Methoxy-5-(Phenylmethoxy)-2-(2-Propenyl)-, 2R-(2.Alpha.,3.Beta.,5.Beta.,6.Alpha.)-
CAS No.	136770-50-8
Molecular Formula	C23H38O4Si
Molecular Weight	406.63 g/mol
Synonyms	(2R,3S,5R,6S)-6-[(tert-Butyldimethylsilyloxy)methyl]-5-methoxy-2-(2-propenyl)-3-(phenylmethoxy)tetrahydro-2H-pyran-2-ol; 2R-(2α,3β,5β,6α)-6-[(tert-Butyldimethylsilyloxy)methyl]tetrahydro-3-methoxy-5-(benzyloxy)-2-(2-propenyl)-2H-pyran-2-ol; tert-Butyldimethyl((2R,3S,5R,6S)-5-methoxy-2-(2-propenyl)-2,3,5,6-tetrahydro-6-((phenylmethoxy)methyl)-2H-pyran-3-yloxy)silane; CAS 136770-50-8; Advanced Pyranol Intermediate; Chiral TBS-protected Pyranol Derivative
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality control protocols to ensure consistency and purity for sensitive synthetic applications. Our standard quality commitment includes comprehensive analysis via HPLC, GC, NMR, and chiral analysis to verify identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical parameters. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled temperature of 2°C to 8°C (refrigerated) for long-term stability. This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For optimal shelf life, containers should be flushed with an inert gas (e.g., nitrogen or argon) after each opening and stored under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.