Description

(3R,4E)-Methyl 3-(Dimethylphenylsilyl)-4-Hexenoate is a chiral organosilicon compound featuring a strategically positioned silyl group and an α,β-unsaturated ester moiety. This unique structure makes it a valuable advanced synthetic intermediate and building block for the stereoselective construction of complex molecules. It is primarily utilized by pharmaceutical research and fine chemical synthesis organizations engaged in the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, particularly for introducing stereocenters adjacent to carbonyl functionalities.
• Asymmetric Synthesis: Serves as a substrate or reagent in stereocontrolled reactions, including silyl-modified conjugate additions and cross-coupling processes.
• Organosilicon Chemistry Research: Used in academic and industrial R&D to study the influence of silyl groups on reaction pathways and molecular properties.
• Ligand and Catalyst Development: Acts as a building block for creating novel chiral ligands or organometallic catalysts used in homogeneous catalysis.
• Material Science Precursor: Potential use in the synthesis of functionalized polymers or hybrid organic-inorganic materials with tailored properties.

Basic Information

Product Name	(3R,4E)-Methyl 3-(Dimethylphenylsilyl)-4-Hexenoate
CAS No.	136174-52-2
Molecular Formula	C15H22O2Si
Molecular Weight	262.42 g/mol
Synonyms	Methyl (3R,4E)-3-[(dimethylphenylsilyl)]-4-hexenoate; (3R,4E)-Methyl 3-(Dimethylphenylsilyl)-4-hexenoate; (E)-(3R)-Methyl 3-(dimethylphenylsilyl)-4-hexenoate; 4-Hexenoic acid, 3-(dimethylphenylsilyl)-, methyl ester, (3R,4E)-; Methyl (3R,4E)-3-(dimethylphenylsilyl)hex-4-enoate; Dimethylphenylsilyl hexenoate methyl ester; Chiral silyl ester intermediate
EINECS	Contact for details

Quality Control

Our production of (3R,4E)-Methyl 3-(Dimethylphenylsilyl)-4-Hexenoate adheres to strict quality management protocols. Each batch is characterized and tested to ensure high chiral purity and chemical identity, with critical parameters including enantiomeric excess (ee) and chemical purity assessed via advanced analytical techniques. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.