Description

(S)-6-Chloromethyl-5,6-Dihydro-Pyran-2-One CAS NO 135999-61-0 is a high-value chiral building block and pharmaceutical intermediate characterized by its lactone ring and reactive chloromethyl group. This compound is essential for the stereoselective synthesis of complex molecules, offering chemists precise control over the three-dimensional architecture of target compounds. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other biologically active molecules requiring specific stereochemistry.
• Asymmetric Synthesis: Used in the construction of complex natural products and chiral ligands where the (S)-configuration is critical for biological activity or material properties.
• Fine Chemical Production: Serves as a versatile precursor for specialty chemicals, agrochemicals, and advanced polymer monomers.
• Academic & Industrial R&D: Employed in medicinal chemistry and process development research for exploring new synthetic routes and optimizing reaction scales.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom compounds for client projects.

Basic Information

Product Name	(S)-6-Chloromethyl-5,6-Dihydro-Pyran-2-One
CAS No.	135999-61-0
Molecular Formula	C6H7ClO2
Molecular Weight	146.57 g/mol
Synonyms	(S)-6-(Chloromethyl)-5,6-dihydro-2H-pyran-2-one; (S)-6-Chloromethyl-5,6-dihydro-2-pyrone; (S)-6-Chloromethyl-dihydro-2-pyrone; (S)-α-Chloromethyl-δ-valerolactone; (S)-5,6-Dihydro-6-(chloromethyl)-2H-pyran-2-one; (S)-Dihydro-6-(chloromethyl)-2-pyrone; (S)-6-Chloromethyldihydropyran-2-one
EINECS	Contact for details

Quality Control

Our (S)-6-Chloromethyl-5,6-Dihydro-Pyran-2-One is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.