Description

3-(5-Chloro-2-Fluoro-Phenyl)-Propionic Acid is a high-purity fluorinated aromatic propionic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique molecular structure, which incorporates both chloro and fluoro substituents to modulate reactivity, lipophilicity, and metabolic stability in target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules where the fluorinated phenylpropionic acid scaffold is desired.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the halogenated aromatic system contributes to efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials, contributing to the dielectric and optical properties of display components.
• Chemical Research & Development: Employed as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fine Chemical Production: Utilized in custom synthesis and contract manufacturing for producing specialized fluorinated compounds.

Basic Information

Item	Details
Product Name	3-(5-Chloro-2-Fluoro-Phenyl)-Propionic Acid
CAS No.	135832-52-9
Molecular Formula	C9H8ClFO2
Molecular Weight	202.61 g/mol
Synonyms	3-(5-Chloro-2-fluorophenyl)propanoic acid; 5-Chloro-2-fluorophenylpropionic acid; 3-(5-Chloro-2-fluorophenyl)propionic acid; 2-Fluoro-5-chlorophenylpropionic acid; β-(5-Chloro-2-fluorophenyl)propionic acid; (5-Chloro-2-fluorophenyl)propanoic acid; 135832-52-9; 3-(5-Chloro-2-fluoro-phenyl)-propionic acid
EINECS	Contact for details

Quality Control

Every batch of 3-(5-Chloro-2-Fluoro-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency meet the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong bases, oxidizing agents, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.