Description

(13R)-5-o-Demethylavermectin A(Sub 1A) Hydrate CAS NO 135681-09-3 is a high-purity, semi-synthetic derivative of the macrocyclic lactone class, specifically an avermectin analog. This compound is of significant commercial and research interest as a key intermediate in the synthesis of advanced agrochemicals and novel pharmaceutical agents. It is primarily sought by manufacturers and R&D facilities in the agrochemical, veterinary pharmaceutical, and life science research sectors for developing next-generation parasiticides and bioactive molecules.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of novel, high-efficacy insecticides and acaricides for crop protection.
• Veterinary Pharmaceutical Research: Used in the development of new antiparasitic formulations for livestock and companion animals.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key building block for creating advanced pharmaceutical compounds targeting parasitic infections.
• Biochemical Research: Employed as a reference standard and tool compound in studies of glutamate-gated chloride channels and neurobiology.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke chemical synthesis projects requiring high-purity, complex molecular scaffolds.

Basic Information

Product Name	(13R)-5-o-Demethylavermectin A(Sub 1A) Hydrate
CAS No.	135681-09-3
Molecular Formula	C48H72O14 • xH2O
Molecular Weight	Approx. 873.1 (Anhydrous basis)
Synonyms	5-O-Desmethylavermectin A1a; 5-O-Demethylavermectin A1a; Demethylavermectin A1a; Avermectin B1a 5-O-Demethyl; (10E,14E,16E)-(1R,4S,5'S,6R,6'R,8R,12S,13S,20R,21R,24S)-6'-[(S)-sec-Butyl]-21,24-dihydroxy-5',11,13,22-tetramethyl-2-oxo-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6-spiro-2'-(5',6'-dihydro-2'H-pyran)-12-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside Hydrate
EINECS	Contact for details

Quality Control

Our (13R)-5-o-Demethylavermectin A(Sub 1A) Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets exacting standards for research and synthesis. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.