Description

Sulfosuccinimidyl Oleate Sodium is a specialized, activated ester derivative of oleic acid, designed for efficient bioconjugation and crosslinking applications. Its core value lies in its ability to covalently link amine-containing molecules, such as proteins or peptides, to hydrophobic moieties or surfaces, facilitating the creation of stable, functionalized materials. This reagent is essential for researchers and manufacturers in the life sciences, pharmaceutical development, and advanced materials sectors who require precise surface modification or the development of targeted delivery systems.

Application

• Protein and Peptide Modification: Conjugation of therapeutic proteins or peptides with lipid chains (e.g., oleic acid) to enhance membrane permeability, alter pharmacokinetics, or create self-assembling structures.
• Lipid Nanoparticle (LNP) Functionalization: Surface engineering of LNPs used in drug and gene delivery systems to attach targeting ligands or stealth polymers (like PEG).
• Biomaterial and Hydrogel Synthesis: Crosslinking agent for creating amine-reactive hydrogels or for covalently immobilizing biomolecules onto polymeric scaffolds for tissue engineering.
• Diagnostic Assay Development: Labeling of antibodies or other detection molecules with hydrophobic tags for use in immunoassays or biosensor platforms.
• Polymer Chemistry: Synthesis of functional polymers and surfactants by introducing reactive N-hydroxysuccinimide (NHS) ester groups onto oleate backbones.
• Surface Coating and Immobilization: Creating reactive surfaces on plates, beads, or chips for the covalent attachment of amine-bearing ligands in microarray technology.

Basic Information

Product Name	Sulfosuccinimidyl Oleate Sodium
CAS No.	135661-44-8
Molecular Formula	C22H36NNaO6S
Molecular Weight	465.58 g/mol
Synonyms	Sodium Sulfosuccinimidyl Oleate; N-Hydroxysulfosuccinimide Oleate Sodium Salt; Sulfo-NHS Oleate; Oleic Acid N-Hydroxysulfosuccinimide Ester Sodium Salt; SOSO; (Z)-Octadec-9-enoic Acid 2,5-Dioxopyrrolidin-1-yl Ester Sulfonate Sodium Salt; 1-[(1-Oxo-9-octadecenyl)oxy]-2,5-pyrrolidinedione 1-Sulfonate Sodium Salt; NHS-Oleate Sulfonate Sodium Salt
EINECS	Contact for details

Quality Control

Our Sulfosuccinimidyl Oleate Sodium is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term stability, store under inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.