Description

4-Cyanobenzylzinc Bromide is a versatile organozinc reagent, a key building block for the formation of carbon-carbon bonds in complex organic synthesis. Its value lies in its high reactivity and selectivity, enabling efficient cross-coupling reactions to introduce the 4-cyanobenzyl moiety into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex aromatic and heterocyclic scaffolds.
• Negishi Cross-Coupling Reactions: Used as a transmetalation agent in palladium-catalyzed couplings with aryl, heteroaryl, or alkenyl halides to form new C-C bonds.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides requiring specific benzyl-substituted structures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Utilized in the synthesis of organic electronic materials, such as molecular wires or components for OLEDs, where the cyano group modifies electronic properties.
• Fine Chemical Production: Applied in the custom synthesis of specialty chemicals, dyes, and pigments.

Basic Information

Product Name	4-Cyanobenzylzinc Bromide
CAS No.	135579-87-2
Molecular Formula	C8H6BrNZn
Molecular Weight	237.43 g/mol
Synonyms	(4-Cyanobenzyl)zinc bromide; Zinc, bromo(4-cyanophenyl)methyl-; p-Cyanobenzylzinc bromide; 4-Cyanobenzyl zinc bromide; (4-Cyanophenylmethyl)zinc bromide; Bromo(4-cyanobenzyl)zinc; (p-Cyanobenzyl)zinc bromide
EINECS	Contact for details

Quality Control

Our 4-Cyanobenzylzinc Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, zinc content, and solution concentration. Our quality systems support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Due to its moisture-sensitive (hygroscopic) and easily oxidized nature, this reagent must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for extended stability. Keep away from strong acids and incompatible solvents. Use appropriate ventilation and handling procedures for pyrophoric organometallic compounds.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (in THF)	0.5 M (Typical)
Assay (Titration)	≥ 95.0%
Zinc Content	Conforms
Identification (IR)	Conforms
Water Content (KF)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.