Description

2,2-Difluoroethyl p-Toluenesulfonate is a specialized organofluorine building block and sulfonate ester of significant value in advanced chemical synthesis. This compound matters for its role as a key reagent in introducing the 2,2-difluoroethyl moiety, a valuable structural motif in medicinal and agrochemical research. Pharmaceutical, agrochemical, and advanced material R&D laboratories require this high-purity intermediate for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those incorporating difluoroethyl ether or thioether groups to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of modern pesticides and herbicides, where the difluoroethyl group can enhance biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or modifying agent in the synthesis of specialty polymers and advanced materials with tailored surface properties or fluorinated characteristics.
• Cross-Coupling Reactions: Acts as an alkylating agent in palladium-catalyzed and other cross-coupling methodologies to construct complex molecular architectures.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands and organocatalysts for asymmetric synthesis and other specialized catalytic processes.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research focused on exploring new methodologies in organofluorine chemistry.

Basic Information

Product Name	2,2-Difluoroethyl p-Toluenesulfonate
CAS No.	135206-84-7
Molecular Formula	C9H10F2O3S
Molecular Weight	236.24 g/mol
Synonyms	2,2-Difluoroethyl Tosylate; p-Toluenesulfonic Acid 2,2-Difluoroethyl Ester; 2,2-Difluoroethyl 4-Methylbenzenesulfonate; 4-Methylbenzenesulfonic Acid 2,2-Difluoroethyl Ester; 1,1-Difluoro-2-[(4-methylphenyl)sulfonyloxy]ethane; 2,2-Difluoroethyl 4-Toluenesulfonate; DFETs; Tosyloxy-1,1-difluoroethane
EINECS	Contact for details

Quality Control

Our 2,2-Difluoroethyl p-Toluenesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.