Description

Tributyl(trifluoromethyl)stannane is a specialized organotin reagent featuring a trifluoromethyl group directly bonded to the tin atom. This compound is valued for its unique reactivity, serving as a versatile source of the trifluoromethyl anion equivalent in various synthetic transformations. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the efficient introduction of the metabolically stable trifluoromethyl group into target molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the late-stage trifluoromethylation of drug candidates to enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Development: Used in the synthesis of novel pesticides and herbicides where the CF3 group improves biological activity and environmental persistence.
• Material Science Research: Employed in the preparation of fluorinated organic semiconductors, liquid crystals, and other advanced functional materials.
• Cross-Coupling Reactions: Acts as a nucleophilic trifluoromethylating agent in Stille-type and other transition metal-catalyzed coupling reactions.
• Nucleophilic Trifluoromethylation: Source of "CF3-" for the trifluoromethylation of a wide range of electrophiles including aldehydes, ketones, and alkyl halides.
• Organic Synthesis Building Block: A critical tool for medicinal and synthetic chemists exploring structure-activity relationships (SAR) through fluorine incorporation.

Basic Information

Product Name	Tributyl(trifluoromethyl)stannane
CAS No.	135039-77-9
Molecular Formula	C13H27F3Sn
Molecular Weight	359.05 g/mol
Synonyms	Trifluoromethyltributylstannane; Tributyl(trifluoromethyl)tin; (Trifluoromethyl)tributylstannane; Stannane, tributyl(trifluoromethyl)-; Tributyltin trifluoromethane; CF3SnBu3; Bu3SnCF3
EINECS	Contact for details

Quality Control

Our Tributyl(trifluoromethyl)stannane is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by NMR (1H, 19F, 119Sn), GC, and other relevant analytical methods. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider maintaining under an inert atmosphere (argon or nitrogen) to preserve reagent quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 95%
1H NMR Assay	Conforms
19F NMR Assay	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.