Description

trans-Hydroxy Praziquantel CAS NO 134924-71-3 is a key pharmaceutical intermediate and metabolite of the anthelmintic drug Praziquantel. This compound is critical for research and development in parasitology, serving as a reference standard and a precursor in the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism studies, impurity profiling, and the development of next-generation antiparasitic treatments.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of Praziquantel and its derivatives.
• Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical labs.
• Metabolite Studies: Essential for in-vitro and in-vivo drug metabolism and pharmacokinetics (DMPK) research related to Praziquantel.
• Impurity Profiling: Employed to identify, quantify, and control related substances in Praziquantel active pharmaceutical ingredient (API) batches.
• Research & Development: Facilitates the discovery and development of new anthelmintic agents and combination therapies.
• Veterinary Medicine: Applied in research for antiparasitic treatments in animal health.

Basic Information

Product Name	trans-Hydroxy Praziquantel
CAS No.	134924-71-3
Molecular Formula	C19H24N2O3
Molecular Weight	328.41 g/mol
Synonyms	(11bRS)-2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one, trans-4-Hydroxy Praziquantel; trans-Praziquantel Metabolite; PZQ Metabolite; Biltricide Metabolite
EINECS	Contact for details

Quality Control

Our trans-Hydroxy Praziquantel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.