Description

Dioleoyl-n-(Monomethoxypolyethylene Glycol Succinyl)Phosphatidylethanolamine is a synthetic, functionalized phospholipid derivative designed for advanced formulation and delivery applications. This compound is engineered to enhance the stability and biocompatibility of lipid-based systems, making it a critical component for creating sophisticated nano-carriers. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing next-generation therapeutic and diagnostic platforms.

Application

• Lipid Nanoparticle (LNP) Formulation: A key excipient for constructing stable, PEGylated lipid nanoparticles used in mRNA and siRNA delivery systems.
• Liposomal Drug Delivery: Incorporated into liposome bilayers to impart stealth properties (PEGylation), prolonging circulation time and reducing immune clearance.
• Diagnostic Agent Encapsulation: Used to create biocompatible shells for contrast agents in medical imaging (e.g., ultrasound, MRI).
• Bioconjugation & Surface Functionalization: Serves as an anchor molecule for attaching targeting ligands (e.g., antibodies, peptides) to lipid-based delivery vehicles.
• Biomimetic Membrane Research: Employed in model membrane studies to investigate the effects of PEGylated lipids on membrane fluidity and protein interactions.
• Cosmetic & Dermal Delivery Systems: A component in advanced nano-emulsions and vesicles for the controlled release of active ingredients in cosmetic products.

Basic Information

Product Name	Dioleoyl-n-(Monomethoxypolyethylene Glycol Succinyl)Phosphatidylethanolamine
CAS No.	133906-05-5
Molecular Formula	CnHmNOpP (Poly-disperse due to PEG chain variation)
Molecular Weight	Variable (Depends on PEG chain length 'n')
Synonyms	DSPE-PEG; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-succinyl]; PEG-DSPE; DSPE-PEG-COOH precursor; mPEG-DSPE; PEGylated DSPE; Poly(ethylene glycol) derivatized phosphatidylethanolamine; DSPE-PEGn (where n is PEG MW); PEGylated Lipid; Stealth Lipid Excipient
EINECS	Contact for details

Quality Control

Our Dioleoyl-n-(Monomethoxypolyethylene Glycol Succinyl)Phosphatidylethanolamine is produced under strict quality management systems. Each batch is characterized using advanced analytical techniques to ensure consistent molecular composition, purity, and functional performance. Certificates of Analysis (COA) detailing specifications for PEG chain length distribution, critical purity parameters, and functional group analysis are provided. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (Purity by HPLC)	≥ 95%
PEG Chain Length (n, avg.)	2000, 3000, 5000 Da (or as specified)
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
Functional Group Analysis	Succinyl & PE moiety confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.