Description

Pyridine, 4-[(Trimethylsilyl)ethynyl]- (9Ci) is a specialized organosilicon building block that combines a pyridine heterocycle with a terminal alkyne protected by a trimethylsilyl (TMS) group. This compound is highly valued for its dual functionality, serving as a versatile synthon in advanced organic synthesis and materials science. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a functionalized pyridine core.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the pyridine moiety imparts specific biological activity.
• Material Science & OLED Development: Acts as a precursor for electron-transport materials, ligands for metal-organic frameworks (MOFs), and components in organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The TMS-protected alkyne allows for selective deprotection and subsequent Sonogashira or other palladium-catalyzed cross-coupling reactions.
• Ligand Synthesis: Utilized for creating sophisticated polydentate ligands for catalysis and coordination chemistry.
• Chemical Research: Serves as a versatile scaffold in academic and industrial R&D for exploring new chemical spaces and reaction methodologies.

Basic Information

Product Name	Pyridine, 4-[(Trimethylsilyl)ethynyl]- (9Ci)
CAS No.	133810-35-2
Molecular Formula	C10H13NSi
Molecular Weight	175.31 g/mol
Synonyms	4-[(Trimethylsilyl)ethynyl]pyridine; 4-(Trimethylsilylethynyl)pyridine; 4-Ethynylpyridine, trimethylsilyl derivative; 4-(2-Trimethylsilylethynyl)pyridine; Pyridine, 4-[2-(trimethylsilyl)ethynyl]-; TMS-Ethynylpyridine; 4-TMS-ethynylpyridine; 4-Pyridyltrimethylsilylacetylene
EINECS	Contact for details

Quality Control

Our production of Pyridine, 4-[(Trimethylsilyl)ethynyl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot is characterized by comprehensive analytical techniques including NMR, HPLC, and GC-MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.