Description

(R)-3-Hydroxy-3-methyl-2-pentanone, also known as 2-Pentanone, 3-Hydroxy-3-Methyl-, (R)- (9Ci) CAS NO 133645-41-7, is a high-value chiral building block and intermediate in organic synthesis. Its defined stereochemistry at the hydroxy-bearing carbon makes it a critical precursor for the production of enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, optically active intermediates for asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Asymmetric Synthesis: Used as a starting material or reagent in catalytic asymmetric reactions to construct complex molecular architectures.
• Agrochemical Production: Serves as a precursor in the manufacture of chiral pesticides and herbicides where biological activity is stereospecific.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, flavors, fragrances, and advanced materials.
• Academic & Industrial Research: A valuable compound for method development in organic chemistry and catalysis studies.

Basic Information

Product Name	(R)-3-Hydroxy-3-methyl-2-pentanone
CAS No.	133645-41-7
Molecular Formula	C6H12O2
Molecular Weight	116.16 g/mol
Synonyms	(R)-3-Hydroxy-3-methylpentan-2-one; (R)-3-Methyl-3-hydroxypentan-2-one; 2-Pentanone, 3-hydroxy-3-methyl-, (R)-; (R)-3-Hydroxy-3-methyl-2-pentanone; (R)-HMK; (R)-3-Hydroxy-3-methylpentan-2-one; (R)-3-Methyl-3-hydroxypentan-2-one; (R)-3-Hydroxy-3-methylpentan-2-one
EINECS	Contact for details

Quality Control

Our (R)-3-Hydroxy-3-methyl-2-pentanone is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Quality is verified through comprehensive analytical techniques including chiral HPLC, GC, and NMR spectroscopy. A Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess (ee), and impurity profile is provided with each shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.