Description

1,1'-[1,3-Phenylenebis-(Methylene)]-Bis-(1,4,7,10-Tetraazacyclododecane) Octahydrochloride is a high-purity, polyazamacrocyclic compound primarily utilized as a sophisticated chelating agent and precursor in advanced chemical synthesis. This product matters for its exceptional ability to form stable complexes with various metal ions, which is critical for applications in catalysis, medical imaging, and materials science. It is needed by research institutions, pharmaceutical developers, and specialty chemical manufacturers working on next-generation diagnostic agents, catalysts, and functional materials.

Application

• MRI Contrast Agent Precursor: Serves as a key intermediate in the synthesis of gadolinium-based and other lanthanide chelates for magnetic resonance imaging (MRI).
• Catalyst Ligand Synthesis: Used to create complex ligands for homogeneous catalysis in fine chemical and pharmaceutical manufacturing processes.
• Radiopharmaceutical Development: Acts as a bifunctional chelator for labeling antibodies, peptides, and other targeting molecules with diagnostic or therapeutic radioisotopes (e.g., 64Cu, 68Ga).
• Metal Ion Scavenging & Separation: Employed in analytical chemistry and environmental science for the selective extraction, separation, or detection of specific metal ions.
• Materials Science Research: Utilized in the development of metal-organic frameworks (MOFs), sensors, and other functional materials where precise metal coordination is required.
• Bioconjugation Chemistry: Functions as a linker or spacer in the conjugation of bioactive molecules to carriers or surfaces for drug delivery and diagnostic applications.

Basic Information

Item	Details
Product Name	1,1'-[1,3-Phenylenebis-(Methylene)]-Bis-(1,4,7,10-Tetraazacyclododecane) Octahydrochloride
CAS No.	133587-10-7
Molecular Formula	C30H68Cl8N12
Molecular Weight	822.66 g/mol
Synonyms	1,3-Phenylenebis(methylene)bis(1,4,7,10-tetraazacyclododecane) octahydrochloride; p-Xylylene-bis(cyclen) octahydrochloride; 1,3-Bis[(1,4,7,10-tetraaza-1-cyclododecyl)methyl]benzene octahydrochloride; Cyclen-p-xylylene derivative octahydrochloride; DO2A-p-xylylene linker octahydrochloride; Bifunctional DOTA derivative octahydrochloride; 1,3-Bis(cyclen-1-ylmethyl)benzene octahydrochloride
EINECS	Contact for details

Quality Control

Our 1,1'-[1,3-Phenylenebis-(Methylene)]-Bis-(1,4,7,10-Tetraazacyclododecane) Octahydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets exacting standards for research and development. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.