Description

Boc-D-Leucine Methyl Ester is a protected amino acid derivative of significant importance in synthetic organic chemistry. This compound serves as a crucial chiral building block for the controlled synthesis of peptides and peptidomimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of D-leucine residues in peptide chains.
• Solution-Phase Peptide Synthesis: Used in the preparation of custom peptides and small protein fragments in solution.
• Pharmaceutical Intermediates: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Employed in the chemical modification of proteins, antibodies, and other biomolecules for research and therapeutic purposes.
• Proteomics Research: Used in the synthesis of isotope-labeled peptides as internal standards for mass spectrometry analysis.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive molecules.

Basic Information

Product Name	Boc-D-Leucine Methyl Ester
CAS No.	133467-01-3
Molecular Formula	C₁₂H₂₃NO₄
Molecular Weight	245.32 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanoic acid methyl ester; Methyl (R)-2-((tert-butoxycarbonyl)amino)-4-methylpentanoate; D-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Boc-D-Leu-OMe; (R)-Methyl 2-((tert-butoxycarbonyl)amino)-4-methylpentanoate; Methyl N-Boc-D-leucinate; N-Boc-D-leucine methyl ester
EINECS	Contact for details

Quality Control

Our Boc-D-Leucine Methyl Ester is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity, essential for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, enantiomeric excess, and impurity profiles. Our quality system is designed to meet the rigorous standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Melting Point	Contact for details
Specific Rotation	Contact for details
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.