Description

(1R)-1-(4-Chlorophenyl)-2-Methylpropan-1-Amine CAS NO 133397-99-6 is a chiral amine compound featuring a chlorophenyl group and an isopropyl moiety, serving as a critical chiral building block in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with high stereochemical purity, which is essential for developing active pharmaceutical ingredients (APIs) and fine chemicals. This product is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to incorporate a specific enantiomer into their synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel APIs, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Catalyst Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric catalysis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high optical purity.
• Academic & Industrial Research: A valuable compound for methodological studies in asymmetric synthesis and chiral resolution techniques.

Basic Information

Product Name	(1R)-1-(4-Chlorophenyl)-2-Methylpropan-1-Amine
CAS No.	133397-99-6
Molecular Formula	C10H14ClN
Molecular Weight	183.68 g/mol
Synonyms	(R)-1-(4-Chlorophenyl)-2-methylpropan-1-amine; (R)-4-Chloro-α-isobutylbenzylamine; (1R)-1-(4-Chlorophenyl)-2-methylpropylamine; (R)-(-)-1-(4-Chlorophenyl)-2-methylpropylamine; (R)-p-Chloro-α-isobutylbenzylamine; (R)-1-(p-Chlorophenyl)-2-methyl-1-propylamine; (R)-1-Amino-1-(4-chlorophenyl)-2-methylpropane
EINECS	Contact for details

Quality Control

Our (1R)-1-(4-Chlorophenyl)-2-Methylpropan-1-Amine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure compliance with customer specifications and high-purity standards. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.