Description

7-Chloro-8-Hydroxy-3-(3'-Fluoropropyl)-1-Phenyl-2,3,4,5-Tetrahydro-3-Benzazepine is a high-purity, advanced pharmaceutical intermediate of significant interest in modern medicinal chemistry. This compound matters for its role as a key synthetic precursor in the development of novel therapeutic agents targeting central nervous system (CNS) disorders. Pharmaceutical R&D teams and fine chemical manufacturers need this benzazepine derivative for its structural complexity and functional groups that enable further chemical modifications. The CAS number for this compound is 133368-69-1.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of potential dopamine receptor ligands and antipsychotic drug candidates.
• Neurological Research: Used in academic and industrial research to study structure-activity relationships (SAR) of benzazepine-based compounds.
• Preclinical Development: Serves as a starting material for creating analogs in drug discovery pipelines focused on neuropsychiatric conditions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Chemical Biology Probes: Utilized to develop tool compounds for investigating specific neurotransmitter pathways and receptor subtypes.
• Process Chemistry: Acts as a key intermediate in scale-up and optimization studies for potential Active Pharmaceutical Ingredient (API) manufacturing.

Basic Information

Product Name	7-Chloro-8-Hydroxy-3-(3'-Fluoropropyl)-1-Phenyl-2,3,4,5-Tetrahydro-3-Benzazepine
CAS No.	133368-69-1
Molecular Formula	C19H21ClFNO
Molecular Weight	333.83 g/mol
Synonyms	7-Chloro-8-hydroxy-3-(3-fluoropropyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 1H-3-Benzazepine, 7-chloro-8-hydroxy-3-(3-fluoropropyl)-1-phenyl-2,3,4,5-tetrahydro-; 3-(3-Fluoropropyl)-7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine; Benzazepine derivative 133368-69-1; 7-Cl-8-OH-3-FP-Phenyl-THB
EINECS	Contact for details

Quality Control

Our 7-Chloro-8-Hydroxy-3-(3'-Fluoropropyl)-1-Phenyl-2,3,4,5-Tetrahydro-3-Benzazepine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.