Description

2-Ethyl-5,7-Dimethyl-3-[2'-(1H-Tetrazole-5-Yl)Biphenyl-4-Ylmethyl]-3H-Imidazo[4,5-B]Pyridine is a high-purity, non-peptidic angiotensin II receptor antagonist intermediate of significant commercial importance. This compound is a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting cardiovascular conditions. It is essential for pharmaceutical R&D laboratories and manufacturers engaged in the production of next-generation antihypertensive and heart failure medications.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor for Sartan-class angiotensin II receptor blockers (ARBs).
• Cardiovascular Drug Research: Crucial for the research and development of novel antihypertensive agents and heart failure treatments.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the final or penultimate steps of API manufacturing under controlled GMP environments.
• Biochemical Research: Used in pharmacological studies to investigate the renin-angiotensin system and receptor binding mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	2-Ethyl-5,7-Dimethyl-3-[2'-(1H-Tetrazole-5-Yl)Biphenyl-4-Ylmethyl]-3H-Imidazo[4,5-B]Pyridine
CAS No.	133240-46-7
Molecular Formula	C26H25N7
Molecular Weight	435.53 g/mol
Synonyms	Valsartan Intermediate; Valsartan Impurity; 2-Ethyl-5,7-dimethyl-3-({4-[2-(2H-tetrazol-5-yl)phenyl]phenyl}methyl)-3H-imidazo[4,5-b]pyridine; 3H-Imidazo[4,5-b]pyridine, 2-ethyl-5,7-dimethyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-; BIBR-277 diethyl ester intermediate; L-158,809 intermediate; Non-peptidic angiotensin II antagonist intermediate.
EINECS	Contact for details

Quality Control

Our 2-Ethyl-5,7-Dimethyl-3-[2'-(1H-Tetrazole-5-Yl)Biphenyl-4-Ylmethyl]-3H-Imidazo[4,5-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with ICH Q7, GMP, and REACH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.