Description

12-(Acetyloxy)-3,6-Dihydroxy-7-Oxocholan-24-Oic Acid Methyl Ester is a high-purity, synthetic bile acid derivative with significant utility in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis of novel therapeutic agents targeting metabolic and hepatic pathways. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex steroid-based drugs and hepatoprotective agents.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical manufacturing (HPLC, LC-MS).
• Biochemical Research: Employed in metabolic studies to investigate bile acid pathways, liver function, and related receptor interactions.
• API Development: Serves as a precursor in the development of new chemical entities (NCEs) for treating cholestatic and metabolic disorders.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for high-value fine chemicals.

Basic Information

Item	Details
Product Name	12-(Acetyloxy)-3,6-Dihydroxy-7-Oxocholan-24-Oic Acid Methyl Ester
CAS No.	133181-56-3
Molecular Formula	C₂₇H₄₂O₈
Molecular Weight	494.62 g/mol
Synonyms	Methyl 12-Acetoxy-3,6-dihydroxy-7-oxo-5β-cholan-24-oate; 7-Oxolithocholic Acid 12-Acetate Methyl Ester; 12-Acetyloxy-3,6-dihydroxy-7-oxocholan-24-oic Acid Methyl Ester; 12α-Acetoxy-3α,6α-dihydroxy-7-oxo-5β-cholan-24-oic Acid Methyl Ester; 7-Ketolithocholic Acid 12-Acetate Methyl Ester; 12-Acetoxy-3,6-dihydroxy-7-oxo-5β-cholan-24-oic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of our 12-(Acetyloxy)-3,6-Dihydroxy-7-Oxocholan-24-Oic Acid Methyl Ester is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your research or production requirements. A detailed Certificate of Analysis (COA), including purity assay and impurity profile, is supplied with each shipment to guarantee product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon) to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.