Description

(1S)-1-(2-Chlorophenyl)-2,2-Dimethylpropane-1,3-Diol is a high-purity chiral diol building block of significant interest in advanced organic synthesis. Its value lies in its rigid, substituted structure which serves as a key intermediate for constructing complex molecules with defined stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, particularly where precise spatial orientation of functional groups is critical for biological activity.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where its structural motif can contribute to specific binding and efficacy.
• Ligand and Catalyst Development: Serves as a backbone for creating chiral ligands and organocatalysts used in asymmetric synthesis to produce enantiomerically pure compounds.
• Material Science Research: Employed as a monomer or cross-linking agent in the development of specialty polymers with unique thermal or mechanical properties.
• Fine Chemical Production: Acts as a building block for synthesizing complex fragrances, flavors, and other high-value specialty chemicals.

Basic Information

Product Name	(1S)-1-(2-Chlorophenyl)-2,2-Dimethylpropane-1,3-Diol
CAS No.	133164-40-6
Molecular Formula	C12H17ClO2
Molecular Weight	228.72 g/mol
Synonyms	(S)-1-(2-Chlorophenyl)-2,2-dimethylpropane-1,3-diol; (1S)-1-(2-Chlorophenyl)-2,2-dimethyl-1,3-propanediol; 2-Chlorophenyl neopentyl glycol (chiral); (S)-2-Chloro-α,α-dimethylbenzenemethanol; (S)-2-(2-Chlorophenyl)-2-hydroxy-3,3-dimethylpropan-1-ol; L-Selectride® reduction product (of corresponding ketone); Chiral chlorophenyl diol
EINECS	Contact for details

Quality Control

Our (1S)-1-(2-Chlorophenyl)-2,2-Dimethylpropane-1,3-Diol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) specifying identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.