Description

(2S,3R)-3-((S)-1-(tert-Butoxycarbonyl)Pyrrolidin-2-Yl)-3-Methoxy-2-Methylpropanoic Acid is a sophisticated chiral building block of significant importance in modern synthetic organic chemistry. Its value lies in its defined stereochemistry and protected functional groups, which enable the efficient and stereoselective construction of complex molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), particularly for novel therapeutic agents.

Application

This advanced chiral intermediate is utilized in a variety of high-value synthetic applications, including:

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting neurological and cardiovascular diseases.
• Peptidomimetic Research: Used to incorporate non-natural amino acid motifs into peptide analogs to enhance stability and bioavailability.
• Asymmetric Synthesis: Serves as a chiral synthon for constructing molecules with specific three-dimensional configurations required for biological activity.
• Medicinal Chemistry & Drug Discovery: Employed in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic entities.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis & Contract Manufacturing: A critical component for fine chemical suppliers offering bespoke synthesis services to the pharma and biotech industries.

Basic Information

Product Name	(2S,3R)-3-((S)-1-(tert-Butoxycarbonyl)Pyrrolidin-2-Yl)-3-Methoxy-2-Methylpropanoic Acid
CAS No.	133164-08-6
Molecular Formula	C15H27NO5
Molecular Weight	301.38 g/mol
Synonyms	Boc-Pyrrolidine-2-yl-3-methoxy-2-methylpropanoic Acid; (2S,3R)-3-Methoxy-2-methyl-3-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]propanoic Acid; (2S,3R)-3-((S)-1-Boc-Pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic Acid; tert-Butyl (2S)-2-[(1R,2S)-1-methoxy-2-methyl-3-oxo-3-propoxy]pyrrolidine-1-carboxylate; Chiral Boc-Protected Amino Acid Derivative; Advanced Pharmaceutical Intermediate 133164-08-6
EINECS	Contact for details

Quality Control

Our production of this high-purity chiral compound adheres to stringent quality protocols. Every batch is characterized and tested to ensure identity, purity, and stereochemical integrity. Quality assurance includes comprehensive analytical methods such as chiral HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with each shipment. We operate under a quality management system designed to meet the exacting standards of pharmaceutical R&D and cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.