Description

1-(2-(Trifluoromethoxy)Phenyl)Hydrazine Hydrochloride is a specialized aromatic hydrazine derivative of significant importance in advanced organic synthesis. Its core value lies in its role as a versatile building block for constructing complex heterocyclic and pharmaceutical scaffolds, particularly those requiring the trifluoromethoxy pharmacophore. This high-purity intermediate is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to introduce key functional groups and modulate the biological activity of target molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances lipophilicity and metabolic stability.
• Heterocyclic Chemistry: Serves as a key reagent for constructing nitrogen-containing heterocycles such as indazoles, pyrazoles, and triazoles through cyclization reactions.
• Material Science Research: Employed in the development of advanced organic materials, including liquid crystals and polymers with specific electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	1-(2-(Trifluoromethoxy)Phenyl)Hydrazine Hydrochloride
CAS No.	133115-76-1
Molecular Formula	C7H8F3N2O·HCl
Molecular Weight	244.61 g/mol
Synonyms	1-(2-(Trifluoromethoxy)phenyl)hydrazine hydrochloride; 1-Hydrazino-2-(trifluoromethoxy)benzene hydrochloride; 2-(Trifluoromethoxy)phenylhydrazine hydrochloride; [2-(Trifluoromethoxy)phenyl]hydrazine hydrochloride; o-(Trifluoromethoxy)phenylhydrazine hydrochloride; 1-(2-Trifluoromethoxyphenyl)hydrazine HCl; Hydrazine, [2-(trifluoromethoxy)phenyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 1-(2-(Trifluoromethoxy)Phenyl)Hydrazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with global regulatory frameworks, and specifications can be aligned with cGMP or other relevant standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.