Description

D-Serine Benzyl Ester Ptsa is a protected amino acid derivative, specifically the benzyl ester of D-serine with p-toluenesulfonic acid (PTSA) as a salt. This compound is a crucial chiral building block in organic synthesis, valued for its role in introducing the D-serine moiety into complex molecules while offering enhanced solubility and handling properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptides, peptidomimetics, and other bioactive compounds where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of D-serine residues, which can influence peptide stability and biological activity.
• Biochemical Research: Serves as a precursor or standard in studies related to amino acid metabolism, enzyme inhibition, and the investigation of neurological pathways involving D-serine.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in asymmetric catalytic reactions to construct complex molecules with high enantiomeric purity.
• Protecting Group Strategy: The benzyl ester group provides a protective function for the carboxylic acid, which can be selectively removed under specific conditions in multi-step synthetic sequences.

Basic Information

Product Name	D-Serine Benzyl Ester Ptsa
CAS No.	133099-80-6
Molecular Formula	C17H21NO6S
Molecular Weight	367.42 g/mol
Synonyms	D-Serine, benzyl ester, p-toluenesulfonate salt; (R)-2-Amino-3-hydroxypropanoic acid benzyl ester 4-methylbenzenesulfonate; Benzyl D-serinate p-toluenesulfonate; D-Ser-OBzl.TosOH; D-Serine benzyl ester tosylate; D-Serine benzyl ester p-toluenesulfonate; (R)-Serine benzyl ester p-toluenesulfonic acid salt
EINECS	Contact for details

Quality Control

Our D-Serine Benzyl Ester Ptsa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing key parameters such as assay, enantiomeric excess, and impurity profiles. While typically supplied as a high-purity research grade, production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and protected from humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.