Description

H-D-Ser-Obzl Hydrochloride Salt is a protected amino acid derivative, specifically the hydrochloride salt of H-D-Serine-O-benzyl ester, with the CAS registry number 133099-79-3. This compound serves as a critical chiral building block in the synthesis of complex peptides and pharmaceutical intermediates, offering precise stereochemical control. It is primarily required by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-serine residues with a protected side chain.
• Biochemical Research: Employed in academic and industrial laboratories for studying enzyme-substrate interactions and protein structure-activity relationships.
• Protecting Group Chemistry: The benzyl (Obzl) protecting group on the serine side chain allows for selective deprotection in multi-step synthetic sequences.
• Ligand and Catalyst Development: Acts as a precursor for creating chiral ligands used in asymmetric catalysis.
• Reference Standard: Serves as a high-purity analytical standard for quality control in pharmaceutical manufacturing.

Basic Information

Product Name	H-D-Ser-Obzl Hydrochloride Salt
CAS No.	133099-79-3
Molecular Formula	C10H14ClNO3
Molecular Weight	231.68 g/mol
Synonyms	H-D-Ser-OBzl HCl; D-Serine, O-benzyl ester, hydrochloride; (R)-2-Amino-3-(benzyloxy)propanoic acid hydrochloride; D-Serine benzyl ester hydrochloride; Boc-D-Ser(Bzl)-OH (related protected form); Fmoc-D-Ser(Bzl)-OH (related protected form); D-Ser(Bzl)-OH·HCl; (R)-3-(Benzyloxy)-2-aminopropanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our H-D-Ser-Obzl Hydrochloride Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.