Description

N'-(tert-Butoxycarbonyl)-n-(9-Fluorenylmethyloxycarbonyl)-D-Lysine Pentafluorophenyl Ester is a highly specialized, dual-protected amino acid derivative designed for advanced peptide synthesis. This compound matters because it serves as a critical building block, enabling the precise and efficient incorporation of D-lysine into complex peptide chains while offering orthogonal deprotection strategies. Pharmaceutical researchers and fine chemical manufacturers need this high-purity reagent for developing therapeutic peptides, peptidomimetics, and other bioactive molecules where stereochemical control is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key activated ester for the controlled, sequential coupling of D-lysine in Fmoc/t-Bu chemistry.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic & Conjugate Synthesis: Facilitates the creation of stable peptide analogs and drug conjugates by providing a reactive handle for amide bond formation.
• Biochemical Research & Proteomics: Employed in the synthesis of labeled peptides, enzyme substrates, and inhibitors for mechanistic studies.
• Custom Peptide Services: An essential raw material for CROs and CDMOs offering bespoke peptide manufacturing.
• Antibody-Drug Conjugate (ADC) Linker Exploration: Used in the design and synthesis of novel, cleavable linker systems.

Basic Information

Product Name	N'-(tert-Butoxycarbonyl)-n-(9-Fluorenylmethyloxycarbonyl)-D-Lysine Pentafluorophenyl Ester
CAS No.	133083-36-0
Molecular Formula	C32H33F5N2O6
Molecular Weight	636.62 g/mol
Synonyms	Boc-Lys(Fmoc)-OPfp; D-Lysine, N6-(9H-fluoren-9-ylmethoxycarbonyl)-N2-[(1,1-dimethylethoxy)carbonyl]-, 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Lys(Boc)-OPfp (D-isomer); Boc-D-Lys(Fmoc)-OPfp ester; (2R)-6-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-{[(2-methylpropan-2-yl)oxy]carbonyl}aminohexanoic acid 2,3,4,5,6-pentafluorophenyl ester; Pentafluorophenyl N6-Fmoc-N2-Boc-D-lysinate; D-Lys(Boc,Fmoc)-OPfp
EINECS	Contact for details

Quality Control

Our production of this peptide synthesis reagent adheres to stringent in-process controls to ensure high chemical purity and stereochemical integrity. Every batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), chiral purity, and related substances is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage under inert atmosphere, contact for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.