Description

5-[4'-(Bromomethyl)-[1,1'-Biphenyl]-2-Yl]-2-(Triphenylmethyl)-2H-Tetrazole is a specialized, high-value organic intermediate featuring a reactive bromomethyl group and a trityl-protected tetrazole moiety. This compound is critical for synthetic chemists requiring precise functional group manipulation and protection strategies in complex molecular assembly. It is primarily utilized in advanced pharmaceutical research and development, particularly in the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals where controlled reactivity is paramount.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially those containing biphenyl or tetrazole pharmacophores.
• Peptide Chemistry: Serves as a precursor for activating agents or protected intermediates used in solid-phase peptide synthesis (SPPS).
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and plant growth regulators requiring specific heterocyclic structures.
• Material Science: Used in the research and development of advanced organic materials, such as liquid crystals or polymers with tailored properties.
• Chemical Biology Probes: Acts as a versatile scaffold for creating labeled compounds or probes used in biochemical assays and diagnostic research.
• Cross-Coupling Reactions: The bromomethyl group makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.

Basic Information

Product Name	5-[4'-(Bromomethyl)-[1,1'-Biphenyl]-2-Yl]-2-(Triphenylmethyl)-2H-Tetrazole
CAS No.	133051-88-4
Molecular Formula	C33H25BrN4
Molecular Weight	557.49 g/mol
Synonyms	2-(Triphenylmethyl)-5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2H-tetrazole; 2-Trityl-5-(2-(4'-bromomethylbiphenyl))tetrazole; 5-(4'-Bromomethylbiphenyl-2-yl)-1-trityl-1H-tetrazole; 2-Trityl-5-(2'-(4-bromomethylphenyl)phenyl)tetrazole; Biphenyl-2-yl-tetrazole derivative; Losartan intermediate derivative; AT1 receptor antagonist intermediate; Tetrazole-protected bromomethyl biphenyl
EINECS	Contact for details

Quality Control

Every batch of 5-[4'-(Bromomethyl)-[1,1'-Biphenyl]-2-Yl]-2-(Triphenylmethyl)-2H-Tetrazole is manufactured and tested under strict quality management systems. We ensure compliance with high-purity standards typical for advanced pharmaceutical intermediates. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom specifications can be developed to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.