Description

Carbamic Acid, [(1S)-2-Fluoro-1-Methyl-2-Oxoethyl]-, 1,1-Dimethylethyl Ester is a high-purity, chiral fluorinated building block of significant interest in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of complex, biologically active molecules, particularly within the pharmaceutical sector. It is primarily sought after by research institutions and manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its specific stereochemistry and fluorine atom are critical for modulating biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), especially in therapeutic areas requiring fluorinated compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine moiety enhances product efficacy and environmental profile.
• Peptidomimetics & Protease Inhibitors: Serves as a building block for constructing peptide analogs and inhibitors that target specific enzymes.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (S)-configured α-fluoro-α-methyl-β-ketoester fragment into target molecules.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies in drug discovery programs focusing on fluorinated analogs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules at various scales.

Basic Information

Product Name	Carbamic Acid, [(1S)-2-Fluoro-1-Methyl-2-Oxoethyl]-, 1,1-Dimethylethyl Ester
CAS No.	133039-96-0
Molecular Formula	C9H16FNO3
Molecular Weight	205.23 g/mol
Synonyms	tert-Butyl (2S)-3-fluoro-2-methyl-3-oxopropan-1-ylcarbamate; (S)-tert-Butyl (3-fluoro-2-methyl-3-oxopropyl)carbamate; (2S)-3-Fluoro-2-methyl-3-oxopropylcarbamic acid tert-butyl ester; N-[(1S)-2-Fluoro-1-methyl-2-oxoethyl]carbamic acid 1,1-dimethylethyl ester; (S)-tert-Butyl (1-fluoro-1-oxopropan-2-yl)carbamate; Boc-L-3-fluoroalanine derivative; Fluorinated Boc-protected amino acid derivative
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(1S)-2-Fluoro-1-Methyl-2-Oxoethyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, NMR, and MS for structural confirmation, to ensure compliance with exacting research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.