Description

(S)-n-tert-Butyl-3-(4-(2-Methoxyphenyl)-Piperazin-1-Yl)-2-Phenylpropanamide Dihydrochloride is a high-purity, pharmacologically relevant chiral compound supplied as a dihydrochloride salt. This product is critical for research and development in medicinal chemistry, offering a key building block for the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on central nervous system (CNS) drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research-scale synthesis of potential drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a reference standard or building block in structure-activity relationship (SAR) studies for compounds interacting with adrenergic or serotonergic systems.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes in pre-clinical and early-phase clinical manufacturing.
• Biochemical Research: Employed in in vitro assays to study ligand-receptor interactions and enzyme inhibition related to its structural class.
• Analytical Standard: Used for method development and validation in analytical laboratories for quality control of related substances.

Basic Information

Item	Details
Product Name	(S)-n-tert-Butyl-3-(4-(2-Methoxyphenyl)-Piperazin-1-Yl)-2-Phenylpropanamide Dihydrochloride
CAS No.	133025-23-7
Molecular Formula	C24H34N3O2 · 2HCl
Molecular Weight	477.47 g/mol (free base: 396.55)
Synonyms	(S)-N-tert-Butyl-3-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylpropanamide dihydrochloride; (S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-1-piperazinyl)-2-phenylpropanamide dihydrochloride; (S)-TBPP Dihydrochloride; (S)-3-(4-(2-Methoxyphenyl)piperazin-1-yl)-2-phenyl-N-(tert-butyl)propanamide dihydrochloride; (S)-WAY-100635 Dihydrochloride (related analog); (S)-N-(tert-Butyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-phenylpropanamide dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-n-tert-Butyl-3-(4-(2-Methoxyphenyl)-Piperazin-1-Yl)-2-Phenylpropanamide Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your critical R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.