Description

n-Cbz-N,n-Bis{2-[(Methylsulfonyl)Oxy]Ethyl}-Amine is a specialized chemical building block featuring a carboxybenzyl (Cbz) protecting group and two mesylate-activated hydroxyl arms. This molecular architecture makes it a critical intermediate for the controlled synthesis of complex nitrogen-containing structures, particularly in advanced pharmaceutical research. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams developing new active pharmaceutical ingredients (APIs) and other high-value compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex amine derivatives and nitrogen heterocycles used in drug discovery and development.
• Protecting Group Chemistry: Utilized in multi-step organic synthesis where the Cbz group protects amines, with the mesylate groups serving as excellent leaving groups for further functionalization.
• Linker Molecule Synthesis: Serves as a precursor for creating bifunctional linkers and spacers in medicinal chemistry, particularly for antibody-drug conjugates (ADCs) and prodrugs.
• Polymer Chemistry: Can be used to introduce amine functionality into polymer backbones or as a cross-linking agent for specialty polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tools for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	n-Cbz-N,n-Bis{2-[(Methylsulfonyl)Oxy]Ethyl}-Amine
CAS No.	133024-90-5
Molecular Formula	C15H23NO8S2
Molecular Weight	409.47 g/mol
Synonyms	Carbobenzoxy-bis(2-mesyloxyethyl)amine; N-Carboxybenzyl-N,N-bis(2-[(methylsulfonyl)oxy]ethyl)amine; Benzyl N,N-bis[2-(methylsulfonyloxy)ethyl]carbamate; Cbz-Bis-Ms-amine; N-Cbz-bis(mesyloxyethyl)amine; N-(Benzyloxycarbonyl)-N,N-bis(2-methanesulfonyloxyethyl)amine; 1,1'-[({[(Benzyloxy)carbonyl]amino}methylidyne)bis(ethane-2,1-diyl)] dimethanesulfonate
EINECS	Contact for details

Quality Control

Our n-Cbz-N,n-Bis{2-[(Methylsulfonyl)Oxy]Ethyl}-Amine is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.