Description

3,5-Difluorobenzamide is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the benzene ring, which can dramatically alter the electronic properties, metabolic stability, and bioavailability of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the difluoro motif enhances biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or building block for creating specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular probe or tag due to the unique properties of fluorine, useful in 19F NMR spectroscopy and binding studies.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3,5-Difluorobenzamide
CAS No.	132980-99-5
Molecular Formula	C7H5F2NO
Molecular Weight	157.12 g/mol
Synonyms	3,5-Difluorobenzoic acid amide; Benzoamide, 3,5-difluoro-; 3,5-Difluorobenzene-1-carboxamide; 1-Carbamoyl-3,5-difluorobenzene; m,m-Difluorobenzamide; 3,5-Difluorobenzenecarboxamide; 3,5-Difluorobenzoylamide
EINECS	Contact for details

Quality Control

Our 3,5-Difluorobenzamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring GMP-grade intermediates and research-standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	145 - 150 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.